It serves as a “quick and easy,” convenient, high-throughput, and automated solution for nematode research.Ĭaenorhabditis elegans nematodes are powerful genetic model organisms which are instrumental for research on a wide range of biological questions. WorMachine is suitable for analysis of a variety of biological questions and provides an accurate and reproducible analysis tool for measuring diverse phenotypes. We examined the power of WorMachine using five separate representative assays: supervised classification of binary-sex phenotype, scoring continuous-sexual phenotypes, quantifying the effects of two different RNA interference treatments, and measuring intracellular protein aggregation.
elegans worms, (2) extraction of morphological features and quantification of fluorescent signals, and (3) machine learning techniques for high-level analysis. We developed WorMachine, a three-step MATLAB-based image analysis software that allows (1) automated identification of C. Caenorhabditis elegans nematodes are powerful model organisms, yet quantification of visible phenotypes is still often labor-intensive, biased, and error-prone.
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